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26 – Chapter 1: Introduction and Objectives

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Chapter 1: Introduction and Objectives

1.1 Introduction

The overall goal of this research is to determine relationships that govern the apparent properties of architectures evaluated solely from a material arrangement standpoint. This work specifically evaluates the structural and material properties of regular architectures that exhibit symmetry, homogeneity, and order. Additionally, this work will evaluate the apparent properties of architectures composed of random pore distributions. These properties and their relationships will be determined through modulation of the solid material and manipulation of the void space. Characterization of these structures will be used in the application of computer aided tissue engineering for the design of novel implants and tailored solutions to clinical problems stemming from tissue defects. Applied focus will be on the design of implants for bone regenerative scaffolds or other mechanically modulated systems. Numerous studies have demonstrated effects of specific scaffold architecture on tissue ingrowth [1-15]. As of yet, no rules have been generated to explain the exact structure’s exact effect nor has any quantifiable difference ever been demonstrated for given architectures as a result of their material organization [16]. Therefore, the global hypothesis of this research is that organization of material affects the structural and material properties of that architecture [17] and ultimately, the success of the implant. Furthermore, the use of design principles to create structures and scaffolds with specific architectures may be used to characterize mechanisms that dictate tissue regeneration in therapeutic scaffolds.

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Written by Matthew Wettergreen

March 22, 2008 at 5:00 am