Thesis or Fecis

It all comes down to this…

Posts Tagged ‘bone

6 – 5:33am, Thesis is done

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I finished my thesis. I don’t feel the glow of accomplishment. I don’t feel the pressure release from completion. I just feel mind fucked.

You can download the the whole thesis if you’re interested but I will warn you that it tops out at 248 pages. If you’re a fan of infoporn, check out the figures. The text is perfect if you are having problems sleeping; you won’t after reading a couple of pages of this document.

My thesis defense will be on Wednesday, April 16th at 1:30pm. This event is free and open to the public. Yes, you’re all invited in case you were waiting for that. I would love to share my research with you. Yes, there is also the possibility of public humiliation.

Matthew Wettergreen Thesis Defense

1:30 – ~3:00pm

Space Sciences 106 (

Parking available across the street from Space Sciences Building

Did you ever see that duck tales episode where Huey, Louie and Duey got ahold of that watch that would stop time? Every minute they had was like a second for the real world? I could use that watch right now cause I feel a Rip Van Winkle caliber nap bubbling up to the surface and tonight better be the LAST time I sleep in the Rice Library.

Written by Matthew Wettergreen

April 10, 2008 at 4:05 am

Posted in thesis

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24 – Chapter 2: Background (Part I)

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The inability of bone to regenerate itself in cases of gross trauma poses a problem still unsolved. The complexity of bone tissue itself is compounded by the requirement that it provide structural support for the patient. Successful treatment should stimulate new bone growth resulting, at the end state, in native bone tissue with no trace of the regenerative device. Bone scaffolds have shown promise in regenerating some critical size defects in non-load bearing anatomic sites but results vary with anatomy and species [1]. Additionally, problems arise in load bearing sites where the scaffold must endure a modicum of mechanical loading. Success requires insight into the mechanisms that dictate bone growth as well as thorough characterization of the intended implanted scaffold. Currently, research has begun to characterize input parameters such as architecture, porosity, permeability and their effect on the resulting tissue ingrowth [2, 3]. The use of techniques such as Computer Aided Tissue Engineering (CATE) may in the future promote the regeneration of a functional bone system where a defect once lay [4]. The following sections will illustrate the importance of structure for function in nature and more specifically in bone. The subsequent architectural discussion will be framed in the effects of specific parameters of architecture and the past work that has attempted to incorporate these concepts into scaffold design.



1. Liebschner, M.A., Biomechanical considerations of animal models used in tissue engineering of bone. Biomaterials, 2004. 25(9): p. 1697-714.

2. Li, S.H., et al., Accurate geometric characterization of macroporous scaffold of tissue engineering. Key Engineering Materials, 2003. 240-242: p. 541-546.

3. Hollister, S.J., et al., Engineering craniofacial scaffolds. Orthod Craniofac Res, 2005. 8(3): p. 162-73.

4. Sun W, D.A., Starly B, Nam J, Computer-Aided Tissue Engineering:Overview, Scope, and Challenges. Biotechnology and Applied Biochemistry, 2004. 39: p. 29-47.




Written by Matthew Wettergreen

March 23, 2008 at 8:00 am

26 – Chapter 1: Introduction and Objectives

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Chapter 1: Introduction and Objectives

1.1 Introduction

The overall goal of this research is to determine relationships that govern the apparent properties of architectures evaluated solely from a material arrangement standpoint. This work specifically evaluates the structural and material properties of regular architectures that exhibit symmetry, homogeneity, and order. Additionally, this work will evaluate the apparent properties of architectures composed of random pore distributions. These properties and their relationships will be determined through modulation of the solid material and manipulation of the void space. Characterization of these structures will be used in the application of computer aided tissue engineering for the design of novel implants and tailored solutions to clinical problems stemming from tissue defects. Applied focus will be on the design of implants for bone regenerative scaffolds or other mechanically modulated systems. Numerous studies have demonstrated effects of specific scaffold architecture on tissue ingrowth [1-15]. As of yet, no rules have been generated to explain the exact structure’s exact effect nor has any quantifiable difference ever been demonstrated for given architectures as a result of their material organization [16]. Therefore, the global hypothesis of this research is that organization of material affects the structural and material properties of that architecture [17] and ultimately, the success of the implant. Furthermore, the use of design principles to create structures and scaffolds with specific architectures may be used to characterize mechanisms that dictate tissue regeneration in therapeutic scaffolds.

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Written by Matthew Wettergreen

March 22, 2008 at 5:00 am